Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM38931
Substrate
n/a
Meas. Tech.
SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay
EC50
19200±n/a nM
Citation
 PubChem, PC SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM38931
Synonyms:
6-methyl-2-[3-methyl-5-(4-methylanilino)-1-pyrazolyl]-1H-pyrimidin-4-one | 6-methyl-2-[3-methyl-5-(4-methylanilino)pyrazol-1-yl]-1H-pyrimidin-4-one | 6-methyl-2-[3-methyl-5-(p-toluidino)pyrazol-1-yl]-1H-pyrimidin-4-one | 6-methyl-2-[3-methyl-5-[(4-methylphenyl)amino]pyrazol-1-yl]-1H-pyrimidin-4-one | MLS000036000 | SMR000062535 | cid_2408467
Type:
Small organic molecule
Emp. Form.:
C16H17N5O
Mol. Mass.:
295.3391
SMILES:
Cc1cc(Nc2ccc(C)cc2)n(n1)-c1nc(C)cc(=O)[nH]1
Structure:
Search PDB for entries with ligand similarity: