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Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM43819
Substrate
n/a
Meas. Tech.
Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS binding at M1
EC50
14360±n/a nM
Citation
 PubChem, PC Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS binding at M1 PubChem Bioassay (2009)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_RAT | Cholinergic, muscarinic M1 | Chrm-1 | Chrm1 | cholinergic receptor, muscarinic 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51390.46
Organism:
RAT
Description:
P08482
Residue:
460
Sequence:
MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM43819
Synonyms:
4-[2-(2-thenoylamino)ethylamino]piperidine-1-carboxylic acid ethyl ester | 4-[2-[[oxo(thiophen-2-yl)methyl]amino]ethylamino]-1-piperidinecarboxylic acid ethyl ester | 4-{2-[(Thiophene-2-carbonyl)-amino]-ethylamino}-piperidine-1-carboxylic acid ethyl ester | VU0177548 | cid_647412 | ethyl 4-[2-(thiophen-2-ylcarbonylamino)ethylamino]piperidine-1-carboxylate | ethyl 4-[2-(thiophene-2-carbonylamino)ethylamino]piperidine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H23N3O3S
Mol. Mass.:
325.426
SMILES:
CCOC(=O)N1CCC(CC1)NCCNC(=O)c1cccs1
Structure:
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