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Target
E3 ubiquitin-protein ligase XIAP
Ligand
BDBM44305
Substrate
n/a
Meas. Tech.
SAR analysis of Antagonists of IAP-family anti-apoptotic proteins
IC50
10500±600 nM
Citation
 PubChem, PC SAR analysis of Antagonists of IAP-family anti-apoptotic proteins PubChem Bioassay (2009)[AID] 
Target
Name:
E3 ubiquitin-protein ligase XIAP
Synonyms:
API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN
Type:
Protein
Mol. Mass.:
56685.27
Organism:
Homo sapiens (Human)
Description:
P98170
Residue:
497
Sequence:
MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENYLGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLTPRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSESDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTPSLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKDSMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDKCPMCYTVITFKQKIFMS
  
Inhibitor
Name:
BDBM44305
Synonyms:
MLS-0412068.0001 | cid_44182183 | formic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)-1-oxopropyl]amino]-N-[(2S)-1-[(4-nitro-1-naphthalenyl)amino]-1-oxopropan-2-yl]butanamide | formic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(2S)-1-[(4-nitronaphthalen-1-yl)amino]-1-oxopropan-2-yl]butanamide | formic acid;(2S)-N-[(1S)-2-keto-1-methyl-2-[(4-nitro-1-naphthyl)amino]ethyl]-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butyramide | methanoic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(2S)-1-[(4-nitronaphthalen-1-yl)amino]-1-oxidanylidene-propan-2-yl]butanamide
Type:
Small organic molecule
Emp. Form.:
C22H29N5O5
Mol. Mass.:
443.4962
SMILES:
CN[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)Nc1ccc([N+]([O-])=O)c2ccccc12
Structure:
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