Reaction Details Report a problem with these data
Target
Tumor necrosis factor ligand superfamily member 10
Ligand
BDBM44371
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells.
IC50
>10000±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells. PubChem Bioassay (2009)[AID] 
Target
Name:
Tumor necrosis factor ligand superfamily member 10
Synonyms:
APO2L | TNF10_HUMAN | TNFSF10 | TRAIL | tumor necrosis factor (ligand) superfamily, member 10
Type:
PROTEIN
Mol. Mass.:
32511.55
Organism:
Homo sapiens (Human)
Description:
EBI_101343
Residue:
281
Sequence:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
  
Inhibitor
Name:
BDBM44371
Synonyms:
2-(ethylthio)-6-phenyl-1H-pyrimidin-4-one | 2-ethylsulfanyl-6-phenyl-1H-pyrimidin-4-one | MLS-0390925.0001 | cid_963514
Type:
Small organic molecule
Emp. Form.:
C12H12N2OS
Mol. Mass.:
232.301
SMILES:
CCSc1nc(cc(=O)[nH]1)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: