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Target
Tumor necrosis factor ligand superfamily member 10
Ligand
BDBM44372
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells.
IC50
602±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that potentiate TRAIL-induced apoptosis in PPC-1 cells. PubChem Bioassay (2009)[AID] 
Target
Name:
Tumor necrosis factor ligand superfamily member 10
Synonyms:
APO2L | TNF10_HUMAN | TNFSF10 | TRAIL | tumor necrosis factor (ligand) superfamily, member 10
Type:
PROTEIN
Mol. Mass.:
32511.55
Organism:
Homo sapiens (Human)
Description:
EBI_101343
Residue:
281
Sequence:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
  
Inhibitor
Name:
BDBM44372
Synonyms:
2-(dichloromethyl)-4-(4-methylphenyl)-6-(methylthio)-1,3,5-triazine | 2-(dichloromethyl)-4-(4-methylphenyl)-6-methylsulfanyl-1,3,5-triazine | 2-(dichloromethyl)-4-(methylthio)-6-(p-tolyl)-s-triazine | 2-[bis(chloranyl)methyl]-4-(4-methylphenyl)-6-methylsulfanyl-1,3,5-triazine | ML100 | MLS-0092727.0002 | cid_3380841
Type:
Small organic molecule
Emp. Form.:
C12H11Cl2N3S
Mol. Mass.:
300.207
SMILES:
CSc1nc(nc(n1)-c1ccc(C)cc1)C(Cl)Cl
Structure:
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