Target
Tumor necrosis factor ligand superfamily member 10
Ligand
BDBM44373
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that potentiate TRAIL-induced apoptosis in MDA-MB-435 cells.
IC50
>10000±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that potentiate TRAIL-induced apoptosis in MDA-MB-435 cells. PubChem Bioassay (2009)[AID] 
Target
Name:
Tumor necrosis factor ligand superfamily member 10
Synonyms:
APO2L | TNF10_HUMAN | TNFSF10 | TRAIL | tumor necrosis factor (ligand) superfamily, member 10
Type:
PROTEIN
Mol. Mass.:
32511.55
Organism:
Homo sapiens (Human)
Description:
EBI_101343
Residue:
281
Sequence:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
  
Inhibitor
Name:
BDBM44373
Synonyms:
2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-1-pyrrolidin-1-yl-propan-1-one | 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-1-pyrrolidin-1-ylpropan-1-one | 2-[[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]thio]-1-(1-pyrrolidinyl)-1-propanone | 2-[[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]thio]-1-pyrrolidino-propan-1-one | MLS-0011658.0001 | cid_3145657
Type:
Small organic molecule
Emp. Form.:
C18H18F3N3OS
Mol. Mass.:
381.415
SMILES:
CC(Sc1nc(cc(n1)C(F)(F)F)-c1ccccc1)C(=O)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: