Reaction Details Report a problem with these data
Target
Tumor necrosis factor ligand superfamily member 10
Ligand
BDBM44377
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that potentiate TRAIL-induced apoptosis in MDA-MB-435 cells.
IC50
>10000±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that potentiate TRAIL-induced apoptosis in MDA-MB-435 cells. PubChem Bioassay (2009)[AID] 
Target
Name:
Tumor necrosis factor ligand superfamily member 10
Synonyms:
APO2L | TNF10_HUMAN | TNFSF10 | TRAIL | tumor necrosis factor (ligand) superfamily, member 10
Type:
PROTEIN
Mol. Mass.:
32511.55
Organism:
Homo sapiens (Human)
Description:
EBI_101343
Residue:
281
Sequence:
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
  
Inhibitor
Name:
BDBM44377
Synonyms:
2-(methylthio)-4-phenyl-6-propan-2-yl-1,3,5-triazine | 2-isopropyl-4-(methylthio)-6-phenyl-s-triazine | 2-methylsulfanyl-4-phenyl-6-propan-2-yl-1,3,5-triazine | MLS-0390943.0001 | cid_25199536
Type:
Small organic molecule
Emp. Form.:
C13H15N3S
Mol. Mass.:
245.343
SMILES:
CSc1nc(nc(n1)-c1ccccc1)C(C)C
Structure:
Search PDB for entries with ligand similarity: