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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM44399
Substrate
n/a
Meas. Tech.
TNAP luminescent HTS assay
IC50
2540±210 nM
Citation
 PubChem, PC TNAP luminescent HTS assay PubChem Bioassay (2008)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM44399
Synonyms:
2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(furan-2-ylmethylcarbamoyl)acetamide | 2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]sulfanyl]-N-(furan-2-ylmethylcarbamoyl)ethanamide | 2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]thio]-N-(2-furfurylcarbamoyl)acetamide | 2-[[5-(2-bromophenyl)-1H-1,2,4-triazol-3-yl]thio]-N-[(2-furanylmethylamino)-oxomethyl]acetamide | MLS000097781 | SMR000063942 | cid_2128115
Type:
Small organic molecule
Emp. Form.:
C16H14BrN5O3S
Mol. Mass.:
436.283
SMILES:
Brc1ccccc1-c1nnc(SCC(=O)NC(=O)NCc2ccco2)[nH]1
Structure:
Search PDB for entries with ligand similarity: