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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM44400
Substrate
n/a
Meas. Tech.
TNAP luminescent HTS assay
IC50
1570±80 nM
Citation
 PubChem, PC TNAP luminescent HTS assay PubChem Bioassay (2008)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM44400
Synonyms:
MLS000098476 | N-(2-furfurylcarbamoyl)-2-[(5-phenyl-1H-1,2,4-triazol-3-yl)thio]acetamide | N-(furan-2-ylmethylcarbamoyl)-2-[(5-phenyl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide | N-(furan-2-ylmethylcarbamoyl)-2-[(5-phenyl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanamide | N-[(2-furanylmethylamino)-oxomethyl]-2-[(5-phenyl-1H-1,2,4-triazol-3-yl)thio]acetamide | SMR000065231 | cid_2669725
Type:
Small organic molecule
Emp. Form.:
C16H15N5O3S
Mol. Mass.:
357.387
SMILES:
O=C(CSc1nnc([nH]1)-c1ccccc1)NC(=O)NCc1ccco1
Structure:
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