Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM44406
Substrate
n/a
Meas. Tech.
TNAP luminescent HTS assay
IC50
>100000±0 nM
Citation
 PubChem, PC TNAP luminescent HTS assay PubChem Bioassay (2008)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM44406
Synonyms:
4-[5-[(2-methoxyphenyl)sulfonylmethyl]-2-furoyl]piperazine-1-carboxylic acid ethyl ester | 4-[[5-[(2-methoxyphenyl)sulfonylmethyl]-2-furanyl]-oxomethyl]-1-piperazinecarboxylic acid ethyl ester | MLS000095160 | SMR000030714 | cid_3241575 | ethyl 4-(5-{[(2-methoxyphenyl)sulfonyl]methyl}-2-furoyl)piperazine-1-carboxylate | ethyl 4-[5-[(2-methoxyphenyl)sulfonylmethyl]furan-2-carbonyl]piperazine-1-carboxylate | ethyl 4-[5-[(2-methoxyphenyl)sulfonylmethyl]furan-2-yl]carbonylpiperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H24N2O7S
Mol. Mass.:
436.479
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)c1ccc(CS(=O)(=O)c2ccccc2OC)o1
Structure:
Search PDB for entries with ligand similarity: