Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM41747
Substrate
n/a
Meas. Tech.
Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS.
EC50
>50000±n/a nM
Citation
 PubChem, PC Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay (2007)[AID] 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM41747
Synonyms:
1-Cyclopentyl-4-[1-(4-fluoro-benzyl)-1H-tetrazol-5-ylmethyl]-piperazine | 1-cyclopentyl-4-[[1-(4-fluorobenzyl)tetrazol-5-yl]methyl]piperazine | 1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-1,2,3,4-tetrazol-5-yl]methyl]piperazine | 1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]-5-tetrazolyl]methyl]piperazine | 1-cyclopentyl-4-[[1-[(4-fluorophenyl)methyl]tetrazol-5-yl]methyl]piperazine | MLS000073054 | SMR000004983 | cid_644709
Type:
Small organic molecule
Emp. Form.:
C18H25FN6
Mol. Mass.:
344.4297
SMILES:
Fc1ccc(Cn2nnnc2CN2CCN(CC2)C2CCCC2)cc1
Structure:
Search PDB for entries with ligand similarity: