Reaction Details Report a problem with these data
Target
Diphosphomevalonate decarboxylase
Ligand
BDBM45750
Substrate
n/a
Meas. Tech.
Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC - Secondary Assay
IC50
734±9980 nM
Citation
 PubChem, PC Screening for Inhibitors of the Mevalonate Pathway in Streptococcus Pneumoniae - DPM-DC - Secondary Assay PubChem Bioassay (2008)[AID] 
Target
Name:
Diphosphomevalonate decarboxylase
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
35571.44
Organism:
Streptococcus pneumoniae D39
Description:
A0A0H2ZN59
Residue:
317
Sequence:
MDREPVTVRSYANIAIIKYWGKKKEKEMVPATSSISLTLENMYTETTLSPLPANVTADEFYINGQLQNEVEHAKMSKIIDRYRPAGEGFVRIDTQNNMPTAAGLSSSSSGLSALVKACNAYFKLGLDRSQLAQEAKFASGSSSRSFYGPLGAWDKDSGEIYPVETDLKLAMIMLVLEDKKKPISSRDGMKLCVETSTTFDDWVRQSEKDYQDMLIYLKENDFAKIGELTEKNALAMHATTKTASPAFSYLTDASYEAMDFVRQLREKGEACYFTMDAGPNVKVFCQEKDLEHLSEIFGQRYRLIVSKTKDLSQDDCC
  
Inhibitor
Name:
BDBM45750
Synonyms:
4-(3-oxidanylidene-1,2-benzothiazol-2-yl)-N-(phenylmethyl)benzamide | 4-(3-oxo-1,2-benzothiazol-2-yl)-N-(phenylmethyl)benzamide | AB00540079 | N-benzyl-4-(3-keto-1,2-benzothiazol-2-yl)benzamide | N-benzyl-4-(3-oxo-1,2-benzothiazol-2-yl)benzamide | cid_16749974
Type:
Small organic molecule
Emp. Form.:
C21H16N2O2S
Mol. Mass.:
360.429
SMILES:
O=C(NCc1ccccc1)c1ccc(cc1)-n1sc2ccccc2c1=O
Structure:
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