Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM50254318
Substrate
n/a
Meas. Tech.
SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay
IC50
289±n/a nM
Citation
 PubChem, PC SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM50254318
Synonyms:
(2,4-dihydrochromeno[4,3-c]pyrazol-3-yl)(pyrrolidin-1-yl)methanone | CHEMBL468052 | cid_16654607
Type:
Small organic molecule
Emp. Form.:
C15H15N3O2
Mol. Mass.:
269.2985
SMILES:
O=C(N1CCCC1)c1[nH]nc-2c1COc1ccccc-21
Structure:
Search PDB for entries with ligand similarity: