Reaction Details Report a problem with these data
Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM45929
Substrate
n/a
Meas. Tech.
SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay
IC50
322±n/a nM
Citation
 PubChem, PC SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM45929
Synonyms:
MLS-0146155.0001 | [3-(2,4-dichloro-5-fluoro-phenyl)-1H-pyrazol-5-yl]-piperidino-methanone | [3-(2,4-dichloro-5-fluorophenyl)-1H-pyrazol-5-yl]-(1-piperidinyl)methanone | [3-(2,4-dichloro-5-fluorophenyl)-1H-pyrazol-5-yl]-piperidin-1-ylmethanone | [3-[2,4-bis(chloranyl)-5-fluoranyl-phenyl]-1H-pyrazol-5-yl]-piperidin-1-yl-methanone | cid_24178132
Type:
Small organic molecule
Emp. Form.:
C15H14Cl2FN3O
Mol. Mass.:
342.196
SMILES:
Fc1cc(-c2cc([nH]n2)C(=O)N2CCCCC2)c(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: