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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM46076
Substrate
n/a
Meas. Tech.
SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay
IC50
253±n/a nM
Citation
 PubChem, PC SAR analysis of an In Vitro TNAP Dose Response Luminescent Assay PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM46076
Synonyms:
3-[2-(3,4-dihydroxyphenyl)ethyl]-8-fluoro-5H-pyrimid[5,4-b]indol-4-one | 3-[2-(3,4-dihydroxyphenyl)ethyl]-8-fluoro-5H-pyrimido[5,4-b]indol-4-one | 3-[2-[3,4-bis(oxidanyl)phenyl]ethyl]-8-fluoranyl-5H-pyrimido[5,4-b]indol-4-one | MLS-0390860.0001 | cid_932151
Type:
Small organic molecule
Emp. Form.:
C18H14FN3O3
Mol. Mass.:
339.3205
SMILES:
Oc1ccc(CCn2cnc3c4cc(F)ccc4[nH]c3c2=O)cc1O
Structure:
Search PDB for entries with ligand similarity: