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Target
Serine/threonine-protein kinase PLK1
Ligand
BDBM46119
Substrate
n/a
Meas. Tech.
Concentration Response fluorescence polarization-based assay to test PMLSC Chemistry Core synthesized analogs of confirmed hits from the Polo box domain (PBD) of Plk1 Primary HTS.
IC50
>50000±n/a nM
Citation
 PubChem, PC Concentration Response fluorescence polarization-based assay to test PMLSC Chemistry Core synthesized analogs of confirmed hits from the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay (2008)[AID] 
Target
Name:
Serine/threonine-protein kinase PLK1
Synonyms:
PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase
Type:
Serine/threonine-protein kinase
Mol. Mass.:
68277.16
Organism:
Homo sapiens (Human)
Description:
P53350
Residue:
603
Sequence:
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
  
Inhibitor
Name:
BDBM46119
Synonyms:
N'-[1-(2,4,6-triketohexahydropyrimidin-5-ylidene)ethyl]isonicotinohydrazide | N'-[1-(2,4,6-trioxo-1,3-diazinan-5-ylidene)ethyl]-4-pyridinecarbohydrazide | N'-[1-(2,4,6-trioxo-1,3-diazinan-5-ylidene)ethyl]pyridine-4-carbohydrazide | N'-[1-[2,4,6-tris(oxidanylidene)-1,3-diazinan-5-ylidene]ethyl]pyridine-4-carbohydrazide | UPDDI-00398622 | cid_5390768
Type:
Small organic molecule
Emp. Form.:
C12H11N5O4
Mol. Mass.:
289.2468
SMILES:
[#6]\[#6](-[#7]-[#7]-[#6](=O)-c1ccncc1)=[#6]-1/[#6](=O)-[#7]-[#6](=O)-[#7]-[#6]-1=O
Structure:
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