Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM33189
Substrate
n/a
Meas. Tech.
Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W.
EC50
25740±n/a nM
Citation
 PubChem, PC Multiplexed dose response screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-W. PubChem Bioassay (2008)[AID] 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM33189
Synonyms:
MLS000727927 | N'-[(1E)-(2,4-dimethoxy-5-nitrophenyl)methylene]isonicotinohydrazide | N-[(2,4-dimethoxy-5-nitro-benzylidene)amino]isonicotinamide | N-[(2,4-dimethoxy-5-nitro-phenyl)methylideneamino]pyridine-4-carboxamide | N-[(2,4-dimethoxy-5-nitrophenyl)methylideneamino]-4-pyridinecarboxamide | N-[(2,4-dimethoxy-5-nitrophenyl)methylideneamino]pyridine-4-carboxamide | N-[(E)-(2,4-dimethoxy-5-nitro-benzylidene)amino]isonicotinamide | SMR000306621 | cid_1510791
Type:
Small organic molecule
Emp. Form.:
C15H14N4O5
Mol. Mass.:
330.2955
SMILES:
COc1cc(OC)c(cc1[CH+][N-]NC(=O)c1ccncc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: