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Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM43259
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
2800±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM43259
Synonyms:
MLS000621545 | N-({[4-({[amino(imino)methyl]amino}sulfonyl)phenyl]amino}carbonothioyl)-1,3-benzodioxole-5-carboxamide | N-[(4-guanidinosulfonylphenyl)thiocarbamoyl]-piperonylamide | N-[[4-(diaminomethylideneamino)sulfonylanilino]-sulfanylidenemethyl]-1,3-benzodioxole-5-carboxamide | N-[[4-(diaminomethylideneamino)sulfonylphenyl]carbamothioyl]-1,3-benzodioxole-5-carboxamide | N-[[4-[bis(azanyl)methylideneamino]sulfonylphenyl]carbamothioyl]-1,3-benzodioxole-5-carboxamide | SMR000299720 | cid_1991728
Type:
Small organic molecule
Emp. Form.:
C16H15N5O5S2
Mol. Mass.:
421.451
SMILES:
NC(=N)NS(=O)(=O)c1ccc(NC(=S)NC(=O)c2ccc3OCOc3c2)cc1
Structure:
Search PDB for entries with ligand similarity: