Reaction Details Report a problem with these data
Target
Ras-related C3 botulinum toxin substrate 1
Ligand
BDBM44154
Substrate
n/a
Meas. Tech.
Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype
EC50
163.8±n/a nM
Citation
 PubChem, PC Multiplexed dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rac wildtype PubChem Bioassay (2010)[AID] 
Target
Name:
Ras-related C3 botulinum toxin substrate 1
Synonyms:
RAC1_MOUSE | Rac1 | Rac1 protein
Type:
PROTEIN
Mol. Mass.:
21455.91
Organism:
Mus musculus
Description:
EBI_101485
Residue:
192
Sequence:
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL
  
Inhibitor
Name:
BDBM44154
Synonyms:
(E)-3-[1-benzyl-3-(4-chlorophenyl)pyrazol-4-yl]acrylic acid | (E)-3-[1-benzyl-3-(4-chlorophenyl)pyrazol-4-yl]prop-2-enoic acid | (E)-3-[3-(4-chlorophenyl)-1-(phenylmethyl)-4-pyrazolyl]-2-propenoic acid | (E)-3-[3-(4-chlorophenyl)-1-(phenylmethyl)pyrazol-4-yl]prop-2-enoic acid | MLS000774997 | SMR000364568 | cid_2474351
Type:
Small organic molecule
Emp. Form.:
C19H15ClN2O2
Mol. Mass.:
338.788
SMILES:
OC(=O)\C=C\c1cn(Cc2ccccc2)nc1-c1ccc(Cl)cc1
Structure:
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