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TargetSerine/threonine-protein kinase D1
LigandBDBM32356
Substrate/Competitorn/a
Meas. Tech.Fluorescence polarization assay for PKD inhibitiors-interference assay-57K HTS campaign
IC50>50000±n/a nM
Citation PubChem, PC Fluorescence polarization assay for PKD inhibitiors-interference assay-57K HTS campaign PubChem Bioassay(2008)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Serine/threonine-protein kinase D1
Name:Protein kinase C, PKC; classical/novel
Synonyms:Protein kinase C mu | Protein kinase C mu type | Protein kinase C mu type (PRKD1) | Protein kinase D | Protein kinase D (PRKD1) | Serine/threonine-protein kinase D1 (PKD1) | nPKC-D1 | nPKC-mu
Type:Serine/threonine-protein kinase
Mol. Mass.:101705.07
Organism:Homo sapiens (Human)
Description:gi_115529463
Residue:912
Sequence:
MSAPPVLRPPSPLLPVAAAAAAAAAALVPGSGPGPAPFLAPVAAPVGGISFHLQIGLSRE
PVLLLQDSSGDYSLAHVREMACSIVDQKFPECGFYGMYDKILLFRHDPTSENILQLVKAA
SDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGC
GLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESF
IGREKRSNSQSYIGRPIHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQ
CKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNSGLMDDM
EEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKS
STVMKEGWMVHYTSKDTLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTS
ALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEIAIQHAL
MPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGG
KHRKTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVME
KLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF
PQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGT
FPFNEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQ
DYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDTPETEET
EMKALGERVSIL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM32356
NameBDBM32356
Synonyms:2-amino-6-chloro-4-methyl-3,5-pyridinedicarbonitrile | 2-amino-6-chloro-4-methyl-dinicotinonitrile | 2-amino-6-chloro-4-methylpyridine-3,5-dicarbonitrile | 2-azanyl-6-chloranyl-4-methyl-pyridine-3,5-dicarbonitrile | MLS000692177 | SMR000333852 | cid_606000
TypeSmall organic molecule
Emp. Form.C8H5ClN4
Mol. Mass.192.605
SMILESCc1c(C#N)c(N)nc(Cl)c1C#N
Structure
n/a