Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43950
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
2793±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43950
Synonyms:
8-{[1-(6-bromo-1,3-benzothiazol-2-yl)piperidin-4-yl]carbonyl}-1,4-dioxa-8-azaspiro[4.5]decane | MLS000093672 | SMR000029290 | [1-(6-bromanyl-1,3-benzothiazol-2-yl)piperidin-4-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone | [1-(6-bromo-1,3-benzothiazol-2-yl)-4-piperidinyl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone | [1-(6-bromo-1,3-benzothiazol-2-yl)-4-piperidyl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone | [1-(6-bromo-1,3-benzothiazol-2-yl)piperidin-4-yl]-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)methanone | cid_3241401
Type:
Small organic molecule
Emp. Form.:
C20H24BrN3O3S
Mol. Mass.:
466.392
SMILES:
Brc1ccc2nc(sc2c1)N1CCC(CC1)C(=O)N1CCC2(CC1)OCCO2
Structure:
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