Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM46351
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
3823±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM46351
Synonyms:
MLS000119730 | N-[4-(diethylamino)-2-methyl-phenyl]-2-(2-ketopyrido[2,3-b][1,4]thiazin-1-yl)acetamide | N-[4-(diethylamino)-2-methyl-phenyl]-2-(2-oxidanylidenepyrido[2,3-b][1,4]thiazin-1-yl)ethanamide | N-[4-(diethylamino)-2-methylphenyl]-2-(2-oxo-1-pyrido[2,3-b][1,4]thiazinyl)acetamide | N-[4-(diethylamino)-2-methylphenyl]-2-(2-oxopyrido[2,3-b][1,4]thiazin-1-yl)acetamide | SMR000096651 | cid_5307179
Type:
Small organic molecule
Emp. Form.:
C20H24N4O2S
Mol. Mass.:
384.495
SMILES:
CCN(CC)c1ccc(NC(=O)CN2C(=O)CSc3ncccc23)c(C)c1
Structure:
Search PDB for entries with ligand similarity: