Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM46374
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
1288±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM46374
Synonyms:
1-(1-acetyl-2,3-dihydroindol-5-yl)-4-hydroxy-3-pyrazolecarboxylic acid methyl ester | 1-(1-acetylindolin-5-yl)-4-hydroxy-pyrazole-3-carboxylic acid methyl ester | MLS000565173 | SMR000152431 | cid_705951 | methyl 1-(1-acetyl-2,3-dihydroindol-5-yl)-4-hydroxypyrazole-3-carboxylate | methyl 1-(1-ethanoyl-2,3-dihydroindol-5-yl)-4-oxidanyl-pyrazole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C15H15N3O4
Mol. Mass.:
301.2973
SMILES:
COC(=O)c1nn(cc1O)-c1ccc2N(CCc2c1)C(C)=O
Structure:
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