Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM46383
Substrate
n/a
Meas. Tech.
Dose response cell-based assay to measure STAT3 inhibition
IC50
8014±n/a nM
Citation
 PubChem, PC Dose response cell-based assay to measure STAT3 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM46383
Synonyms:
6-chloranyl-4-phenyl-3-(1-phenyl-1,2,3,4-tetrazol-5-yl)quinoline | 6-chloro-4-phenyl-3-(1-phenyl-1H-tetraazol-5-yl)quinoline | 6-chloro-4-phenyl-3-(1-phenyl-5-tetrazolyl)quinoline | 6-chloro-4-phenyl-3-(1-phenyltetrazol-5-yl)quinoline | MLS000546032 | SMR000163461 | cid_1046836
Type:
Small organic molecule
Emp. Form.:
C22H14ClN5
Mol. Mass.:
383.833
SMILES:
Clc1ccc2ncc(-c3nnnn3-c3ccccc3)c(-c3ccccc3)c2c1
Structure:
Search PDB for entries with ligand similarity: