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Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM46339
Substrate
n/a
Meas. Tech.
Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition
IC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM46339
Synonyms:
4-Amino-3-cyclohexylcarbamoyl-isothiazole-5-carboxylic acid cyclohexylcarbamoylmethyl ester | 4-amino-3-(cyclohexylcarbamoyl)isothiazole-5-carboxylic acid [2-(cyclohexylamino)-2-keto-ethyl] ester | 4-amino-3-[(cyclohexylamino)-oxomethyl]-5-isothiazolecarboxylic acid [2-(cyclohexylamino)-2-oxoethyl] ester | MLS000031169 | SMR000006300 | [2-(cyclohexylamino)-2-oxidanylidene-ethyl] 4-azanyl-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate | [2-(cyclohexylamino)-2-oxoethyl] 4-amino-3-(cyclohexylcarbamoyl)-1,2-thiazole-5-carboxylate | cid_651494
Type:
Small organic molecule
Emp. Form.:
C19H28N4O4S
Mol. Mass.:
408.515
SMILES:
Nc1c(nsc1C(=O)OCC(=O)NC1CCCCC1)C(=O)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: