Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM46372
Substrate
n/a
Meas. Tech.
Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition
IC50
>55700±n/a nM
Citation
 PubChem, PC Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition PubChem Bioassay (2008)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM46372
Synonyms:
MLS000554850 | SMR000146967 | cid_9551755
Type:
Small organic molecule
Emp. Form.:
C24H16N2O
Mol. Mass.:
348.3966
SMILES:
[H][C@]12C(C(=O)n3c1nc1ccccc31)C1([H])c3ccccc3C2([H])c2ccccc12 |wU:1.0,TLB:3:2:21.16:24.29,20:21:1.2:24.29,25:24:1.2:21.16,THB:28:29:1.2:21.16,17:16:1.2:24.29,6:1:21.16:24.29,(9.29,-2.64,;8.66,-1.54,;7.91,-.24,;6.45,-.55,;5.34,.45,;6.3,-2.03,;7.66,-2.64,;7.5,-4.11,;6.05,-4.41,;5.3,-5.76,;3.76,-5.77,;2.99,-4.44,;3.77,-3.11,;5.31,-3.13,;11.63,1.41,;11.64,.48,;11.08,3.42,;11.1,4.98,;9.76,5.77,;8.41,4.99,;8.42,3.43,;9.78,2.67,;11.25,-.04,;11.31,-.97,;13.99,-1.18,;15.07,-2.29,;16.58,-1.9,;16.98,-.4,;15.87,.7,;14.37,.27,)|
Structure:
Search PDB for entries with ligand similarity: