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Target
Mannose-6-phosphate isomerase
Ligand
BDBM46646
Substrate
n/a
Meas. Tech.
Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.
IC50
7510±n/a nM
Citation
 PubChem, PC Confirmation of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay (2010)[AID] 
Target
Name:
Mannose-6-phosphate isomerase
Synonyms:
MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1
Type:
PROTEIN
Mol. Mass.:
46651.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448919
Residue:
423
Sequence:
MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAKILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEKLHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLKQTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQLHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTPKFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYKVLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRACCLL
  
Inhibitor
Name:
BDBM46646
Synonyms:
2-(5-morpholin-4-ylsulfonyl-2-pyrrolidin-1-yl-phenyl)-1,2-benzothiazol-3-one | 2-(5-morpholin-4-ylsulfonyl-2-pyrrolidin-1-ylphenyl)-1,2-benzothiazol-3-one | 2-(5-morpholinosulfonyl-2-pyrrolidino-phenyl)-1,2-benzothiazol-3-one | 2-[5-(4-morpholinylsulfonyl)-2-(1-pyrrolidinyl)phenyl]-1,2-benzothiazol-3-one | MLS-0069818.0001 | cid_2327938
Type:
Small organic molecule
Emp. Form.:
C21H23N3O4S2
Mol. Mass.:
445.555
SMILES:
O=c1n(sc2ccccc12)-c1cc(ccc1N1CCCC1)S(=O)(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: