Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM32750
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
2580±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM32750
Synonyms:
MLS000567354 | N-methyl-N-(2-phenoxyethyl)-5-(1-piperidinylsulfonyl)-2-pyridinamine | N-methyl-N-(2-phenoxyethyl)-5-piperidin-1-ylsulfonyl-pyridin-2-amine | N-methyl-N-(2-phenoxyethyl)-5-piperidin-1-ylsulfonylpyridin-2-amine | SMR000154138 | cid_4885397 | methyl-(2-phenoxyethyl)-(5-piperidinosulfonyl-2-pyridyl)amine
Type:
Small organic molecule
Emp. Form.:
C19H25N3O3S
Mol. Mass.:
375.485
SMILES:
CN(CCOc1ccccc1)c1ccc(cn1)S(=O)(=O)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: