Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46892
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
1830±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46892
Synonyms:
4'-(2-methoxyphenyl)-4',5',6,7,8,9-hexahydrospiro(5H-benzo[a]cycloheptene-6,5'-[3'H]-pyrazole)-5-one | 4-(2-methoxyphenyl)-5'-spiro[3,4-dihydropyrazole-5,6'-8,9-dihydro-7H-benzo[7]annulene]one | 4-(2-methoxyphenyl)spiro[1-pyrazoline-3,6'-8,9-dihydro-7H-benzocycloheptene]-5'-one | 4-(2-methoxyphenyl)spiro[3,4-dihydropyrazole-5,6'-8,9-dihydro-7H-benzo[7]annulene]-5'-one | MLS000544738 | SMR000163970 | cid_4141059
Type:
Small organic molecule
Emp. Form.:
C20H20N2O2
Mol. Mass.:
320.385
SMILES:
COc1ccccc1C1CN=NC11CCCc2ccccc2C1=O |c:11|
Structure:
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