Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46916
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
17100±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46916
Synonyms:
2-[5-(4-Fluoro-phenyl)-1-propyl-1H-imidazol-2-ylsulfanyl]-N-[4-(piperidine-1-sulfonyl)-phenyl]-acetamide | 2-[5-(4-fluorophenyl)-1-propyl-imidazol-2-yl]sulfanyl-N-(4-piperidin-1-ylsulfonylphenyl)ethanamide | 2-[5-(4-fluorophenyl)-1-propylimidazol-2-yl]sulfanyl-N-(4-piperidin-1-ylsulfonylphenyl)acetamide | 2-[[5-(4-fluorophenyl)-1-propyl-2-imidazolyl]thio]-N-[4-(1-piperidinylsulfonyl)phenyl]acetamide | 2-[[5-(4-fluorophenyl)-1-propyl-imidazol-2-yl]thio]-N-(4-piperidinosulfonylphenyl)acetamide | MLS000548651 | SMR000171069 | cid_3212443
Type:
Small organic molecule
Emp. Form.:
C25H29FN4O3S2
Mol. Mass.:
516.651
SMILES:
CCCn1c(SCC(=O)Nc2ccc(cc2)S(=O)(=O)N2CCCCC2)ncc1-c1ccc(F)cc1
Structure:
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