Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46924
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
>29900±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46924
Synonyms:
2-methyl-2-[(3-methylbenzyl)-(3-nitrophenyl)sulfonyl-amino]propionic acid ethyl ester | 2-methyl-2-[(3-methylphenyl)methyl-(3-nitrophenyl)sulfonylamino]propanoic acid ethyl ester | MLS000586606 | SMR000207985 | cid_12005643 | ethyl 2-methyl-2-[(3-methylphenyl)methyl-(3-nitrophenyl)sulfonyl-amino]propanoate | ethyl 2-methyl-2-[(3-methylphenyl)methyl-(3-nitrophenyl)sulfonylamino]propanoate | ethyl 2-methyl-N-(3-methylbenzyl)-N-[(3-nitrophenyl)sulfonyl]alaninate
Type:
Small organic molecule
Emp. Form.:
C20H24N2O6S
Mol. Mass.:
420.479
SMILES:
CCOC(=O)C(C)(C)N(Cc1cccc(C)c1)S(=O)(=O)c1cccc(c1)[N+]([O-])=O
Structure:
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