Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46925
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
10400±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46925
Synonyms:
2-Fluoro-benzoic acid N'-(2-hydroxy-2,2-diphenyl-acetyl)-N-phenyl-hydrazide | 2-fluoranyl-N'-(2-oxidanyl-2,2-diphenyl-ethanoyl)-N-phenyl-benzohydrazide | 2-fluoro-N'-(2-hydroxy-1-oxo-2,2-diphenylethyl)-N-phenylbenzohydrazide | 2-fluoro-N'-(2-hydroxy-2,2-diphenylacetyl)-N-phenylbenzohydrazide | MLS000589444 | N'-benziloyl-2-fluoro-N-phenyl-benzohydrazide | SMR000212894 | cid_1040178
Type:
Small organic molecule
Emp. Form.:
C27H21FN2O3
Mol. Mass.:
440.4656
SMILES:
OC(C(=O)NN(C(=O)c1ccccc1F)c1ccccc1)(c1ccccc1)c1ccccc1
Structure:
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