Reaction Details Report a problem with these data
Target
Mucolipin-3
Ligand
BDBM46935
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
2800±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46935
Synonyms:
2-[[2-[(2S)-3-methyl-2-(tosylamino)butanoyl]oxyacetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid methyl ester | 2-[[2-[(2S)-3-methyl-2-[(4-methylphenyl)sulfonylamino]-1-oxobutoxy]-1-oxoethyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylic acid methyl ester | MLS000393838 | SMR000247950 | cid_2105155 | methyl 2-[2-[(2S)-3-methyl-2-[(4-methylphenyl)sulfonylamino]butanoyl]oxyethanoylamino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate | methyl 2-[[2-[(2S)-3-methyl-2-[(4-methylphenyl)sulfonylamino]butanoyl]oxyacetyl]amino]-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C23H28N2O7S2
Mol. Mass.:
508.608
SMILES:
COC(=O)c1c(NC(=O)COC(=O)[C@@H](NS(=O)(=O)c2ccc(C)cc2)C(C)C)sc2CCCc12
Structure:
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