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Target
Mucolipin-3
Ligand
BDBM46937
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
>1110±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46937
Synonyms:
1-[bis(bromanyl)methyl]-6-bromanyl-N-tert-butyl-5,5-dimethyl-bicyclo[2.1.1]hexane-4-carboxamide | 6-bromo-N-(tert-butyl)-4-(dibromomethyl)-5,5-dimethylbicyclo[2.1.1]hexane-1-carboxamide | 6-bromo-N-tert-butyl-1-(dibromomethyl)-5,5-dimethyl-4-bicyclo[2.1.1]hexanecarboxamide | 6-bromo-N-tert-butyl-1-(dibromomethyl)-5,5-dimethyl-bicyclo[2.1.1]hexane-4-carboxamide | 6-bromo-N-tert-butyl-1-(dibromomethyl)-5,5-dimethylbicyclo[2.1.1]hexane-4-carboxamide | MLS000700633 | SMR000225336 | cid_4225066
Type:
Small organic molecule
Emp. Form.:
C14H22Br3NO
Mol. Mass.:
460.043
SMILES:
CC(C)(C)NC(=O)C12CCC(C(Br)Br)(C1Br)C2(C)C
Structure:
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