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Target
Mucolipin-3
Ligand
BDBM46990
Substrate
n/a
Meas. Tech.
Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3)
EC50
4590±n/a nM
Citation
 PubChem, PC Dose response cell-based high-throughput screening assay for agonists of the transient receptor potential channel ML3 (TRPML3) PubChem Bioassay (2009)[AID] 
Target
Name:
Mucolipin-3
Synonyms:
MCLN3_HUMAN | MCOLN3 | MCOLN3 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
64244.09
Organism:
Homo sapiens (Human)
Description:
Q8TDD5
Residue:
553
Sequence:
MADPEVVVSSCSSHEEENRCNFNQQTSPSEELLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVLFGLSNQMVVAFKEENTIAFKHLFLKGYMDRMDDTYAVYTQSDVYDQLIFAVNQYLQLYNVSVGNHAYENKGTKQSAMAICQHFYKRGNIYPGNDTFDIDPEIETECFFVEPDEPFHIGTPAENKLNLTLDFHRLLTVELQFKLKAINLQTVRHQELPDCYDFTLTITFDNKAHSGRIKISLDNDISIRECKDWHVSGSIQKNTHYMMIFDAFVILTCLVSLILCIRSVIRGLQLQQEFVNFFLLHYKKEVSVSDQMEFVNGWYIMIIISDILTIIGSILKMEIQAKSLTSYDVCSILLGTSTMLVWLGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHDKFRSLNMVSECLFSLINGDDMFATFAKMQQKSYLVWLFSRIYLYSFISLFIYMILSLFIALITDTYETIKQYQQDGFPETELRTFISECKDLPNSGKYRLEDDPPVSLFCCCKK
  
Inhibitor
Name:
BDBM46990
Synonyms:
MLS000861359 | N-(2,4-dichlorophenyl)-N-ethyl-6-methoxy-4-(trifluoromethyl)-3-pyridinecarboxamide | N-(2,4-dichlorophenyl)-N-ethyl-6-methoxy-4-(trifluoromethyl)nicotinamide | N-(2,4-dichlorophenyl)-N-ethyl-6-methoxy-4-(trifluoromethyl)pyridine-3-carboxamide | SMR000460143 | cid_2727009
Type:
Small organic molecule
Emp. Form.:
C16H13Cl2F3N2O2
Mol. Mass.:
393.188
SMILES:
CCN(C(=O)c1cnc(OC)cc1C(F)(F)F)c1ccc(Cl)cc1Cl
Structure:
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