Reaction Details Report a problem with these data
Target
Phosphomannomutase 2
Ligand
BDBM44372
Substrate
n/a
Meas. Tech.
Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay
IC50
>100000±n/a nM
Citation
 PubChem, PC Counter screen SAR assay for PMM2 inhibitors via a fluorescence intensity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Phosphomannomutase 2
Synonyms:
PMM2 | PMM2_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
28082.33
Organism:
Homo sapiens (Human)
Description:
gi_4557839
Residue:
246
Sequence:
MAAPGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQEQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYCLSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENIRQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKTIYFFGDKTMPGGNDHEIFTDPRTMGYSVTAPEDTRRICELLFS
  
Inhibitor
Name:
BDBM44372
Synonyms:
2-(dichloromethyl)-4-(4-methylphenyl)-6-(methylthio)-1,3,5-triazine | 2-(dichloromethyl)-4-(4-methylphenyl)-6-methylsulfanyl-1,3,5-triazine | 2-(dichloromethyl)-4-(methylthio)-6-(p-tolyl)-s-triazine | 2-[bis(chloranyl)methyl]-4-(4-methylphenyl)-6-methylsulfanyl-1,3,5-triazine | ML100 | MLS-0092727.0002 | cid_3380841
Type:
Small organic molecule
Emp. Form.:
C12H11Cl2N3S
Mol. Mass.:
300.207
SMILES:
CSc1nc(nc(n1)-c1ccc(C)cc1)C(Cl)Cl
Structure:
Search PDB for entries with ligand similarity: