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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
Ligand
BDBM47376
Substrate
n/a
Meas. Tech.
Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen
EC50
4600±n/a nM
Citation
 PubChem, PC Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen PubChem Bioassay (2009)[AID] 
Target
Name:
Broad substrate specificity ATP-binding cassette transporter ABCG2
Synonyms:
ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter
Type:
Multi-pass membrane protein; monomer or homodimer; disulfide-linked
Mol. Mass.:
72329.48
Organism:
Homo sapiens (Human)
Description:
Q9UNQ0
Residue:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
  
Inhibitor
Name:
BDBM47376
Synonyms:
4-[1-[benzyl-[2-(2-thienyl)acetyl]amino]-2-(cyclohexylamino)-2-keto-ethyl]benzoic acid methyl ester | 4-[2-(cyclohexylamino)-2-oxo-1-[(1-oxo-2-thiophen-2-ylethyl)-(phenylmethyl)amino]ethyl]benzoic acid methyl ester | UNM000011096701 | cid_3191162 | methyl 4-[1-[benzyl-(2-thiophen-2-ylacetyl)amino]-2-(cyclohexylamino)-2-oxoethyl]benzoate | methyl 4-[2-(cyclohexylamino)-2-oxidanylidene-1-[(phenylmethyl)-(2-thiophen-2-ylethanoyl)amino]ethyl]benzoate
Type:
Small organic molecule
Emp. Form.:
C29H32N2O4S
Mol. Mass.:
504.64
SMILES:
COC(=O)c1ccc(cc1)C(N(Cc1ccccc1)C(=O)Cc1cccs1)C(=O)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: