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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
Ligand
BDBM47378
Substrate
n/a
Meas. Tech.
Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen
EC50
4880±n/a nM
Citation
 PubChem, PC Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen PubChem Bioassay (2009)[AID] 
Target
Name:
Broad substrate specificity ATP-binding cassette transporter ABCG2
Synonyms:
ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter
Type:
Multi-pass membrane protein; monomer or homodimer; disulfide-linked
Mol. Mass.:
72329.48
Organism:
Homo sapiens (Human)
Description:
Q9UNQ0
Residue:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
  
Inhibitor
Name:
BDBM47378
Synonyms:
3-(5-bromanylfuran-2-yl)-5-(2-nitrophenyl)-1,2,4-oxadiazole | 3-(5-bromo-2-furanyl)-5-(2-nitrophenyl)-1,2,4-oxadiazole | 3-(5-bromo-2-furyl)-5-(2-nitrophenyl)-1,2,4-oxadiazole | 3-(5-bromofuran-2-yl)-5-(2-nitrophenyl)-1,2,4-oxadiazole | UNM000011096901 | cid_717872
Type:
Small organic molecule
Emp. Form.:
C12H6BrN3O4
Mol. Mass.:
336.098
SMILES:
[O-][N+](=O)c1ccccc1-c1nc(no1)-c1ccc(Br)o1
Structure:
Search PDB for entries with ligand similarity: