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Target
Broad substrate specificity ATP-binding cassette transporter ABCG2
Ligand
BDBM33771
Substrate
n/a
Meas. Tech.
Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen
EC50
1570±n/a nM
Citation
 PubChem, PC Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen PubChem Bioassay (2009)[AID] 
Target
Name:
Broad substrate specificity ATP-binding cassette transporter ABCG2
Synonyms:
ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter
Type:
Multi-pass membrane protein; monomer or homodimer; disulfide-linked
Mol. Mass.:
72329.48
Organism:
Homo sapiens (Human)
Description:
Q9UNQ0
Residue:
655
Sequence:
MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
  
Inhibitor
Name:
BDBM33771
Synonyms:
(6-nitro-4H-1,3-benzodioxin-8-yl)methyl 2-(benzenesulfonamido)-3-methylbutanoate | (6-nitro-4H-1,3-benzodioxin-8-yl)methyl 3-methyl-2-(phenylsulfonylamino)butanoate | 2-(benzenesulfonamido)-3-methyl-butyric acid (6-nitro-4H-1,3-benzodioxin-8-yl)methyl ester | 2-(benzenesulfonamido)-3-methylbutanoic acid (6-nitro-4H-1,3-benzodioxin-8-yl)methyl ester | MLS000393258 | SMR000248052 | cid_5131866
Type:
Small organic molecule
Emp. Form.:
C20H22N2O8S
Mol. Mass.:
450.462
SMILES:
CC(C)C(NS(=O)(=O)c1ccccc1)C(=O)OCc1cc(cc2COCOc12)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: