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TargetMuscarinic acetylcholine receptor M2
LigandBDBM43820
Substrate/Competitorn/a
Meas. Tech.Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2
EC50 92350±n/a nM
Citation PubChem, PC Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist NMS competition at M2 PubChem Bioassay(2009)[AID]
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2 and M5
Synonyms:CHRM2 | Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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  Blast E-value cutoff:
BDBM43820
NameBDBM43820
Synonyms:4-[2-(2-Chloro-benzoylamino)-ethylamino]-piperidine-1-carboxylic acid ethyl ester | 4-[2-[(2-chlorobenzoyl)amino]ethylamino]piperidine-1-carboxylic acid ethyl ester | 4-[2-[[(2-chlorophenyl)-oxomethyl]amino]ethylamino]-1-piperidinecarboxylic acid ethyl ester | VU0207811 | cid_644390 | ethyl 4-[2-[(2-chlorobenzoyl)amino]ethylamino]piperidine-1-carboxylate | ethyl 4-[2-[(2-chlorophenyl)carbonylamino]ethylamino]piperidine-1-carboxylate
TypeSmall organic molecule
Emp. Form.C17H24ClN3O3
Mol. Mass.353.844
SMILESCCOC(=O)N1CCC(CC1)NCCNC(=O)c1ccccc1Cl
Structure
n/a