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Target
Regulator of G-protein signaling 8
Ligand
BDBM47740
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47740
Synonyms:
1-ethyl-4-(4-fluoranyl-2-nitro-5-pyrrolidin-1-yl-phenyl)piperazine | 1-ethyl-4-(4-fluoro-2-nitro-5-pyrrolidin-1-ylphenyl)piperazine | 1-ethyl-4-(4-fluoro-2-nitro-5-pyrrolidino-phenyl)piperazine | 1-ethyl-4-[4-fluoro-2-nitro-5-(1-pyrrolidinyl)phenyl]piperazine | MLS000585707 | SMR000204270 | cid_12005086
Type:
Small organic molecule
Emp. Form.:
C16H23FN4O2
Mol. Mass.:
322.3778
SMILES:
CCN1CCN(CC1)c1cc(N2CCCC2)c(F)cc1[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: