Reaction Details Report a problem with these data
Target
Regulator of G-protein signaling 8
Ligand
BDBM47764
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
5130±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47764
Synonyms:
(4E)-5-methyl-4-[[3-[[(Z)-(3-methyl-1-phenyl-5-sulfanylidene-4-pyrazolylidene)methyl]amino]propylamino]methylidene]-2-phenyl-3-pyrazolethione | (4E)-5-methyl-4-[[3-[[(Z)-(3-methyl-1-phenyl-5-sulfanylidene-pyrazol-4-ylidene)methyl]amino]propylamino]methylidene]-2-phenyl-pyrazole-3-thione | (4E)-5-methyl-4-[[3-[[(Z)-(3-methyl-1-phenyl-5-sulfanylidenepyrazol-4-ylidene)methyl]amino]propylamino]methylidene]-2-phenylpyrazole-3-thione | (4E)-5-methyl-4-[[3-[[(Z)-(3-methyl-1-phenyl-5-thioxo-2-pyrazolin-4-ylidene)methyl]amino]propylamino]methylene]-2-phenyl-2-pyrazoline-3-thione | 3-methyl-4-{[(3-{[(3-methyl-1-phenyl-5-sulfanyl-1H-pyrazol-4-yl)methylene]amino}propyl)imino]methyl}-1-phenyl-1H-pyrazole-5-thiol | MLS000701800 | SMR000225437 | cid_5581000
Type:
Small organic molecule
Emp. Form.:
C25H26N6S2
Mol. Mass.:
474.644
SMILES:
Cc1[nH]n(-c2ccccc2)c(=S)c1C=NCCCN=Cc1c(C)[nH]n(-c2ccccc2)c1=S |w:14.16,18.19|
Structure:
Search PDB for entries with ligand similarity: