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Target
Regulator of G-protein signaling 8
Ligand
BDBM47795
Substrate
n/a
Meas. Tech.
Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose respone, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS8-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 8
Synonyms:
RGS8 | RGS8_HUMAN | Regulator of G-protein signaling 8 (RGS8)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
20925.80
Organism:
Homo sapiens (Human)
Description:
gi_74355113
Residue:
180
Sequence:
MAALLMPRRNKGMRTRLGCLSHKSDSCSDFTAILPDKPNRALKRLSTEEATRWADSFDVLLSHKYGVAAFRAFLKTEFSEENLEFWLACEEFKKTRSTAKLVSKAHRIFEEFVDVQAPREVNIDFQTREATRKNLQEPSLTCFDQAQGKVHSLMEKDSYPRFLRSKMYLDLLSQSQRRLS
  
Inhibitor
Name:
BDBM47795
Synonyms:
MLS000686223 | N-[2-(2-methoxyphenyl)ethyl]-2-[(6-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulfanyl]acetamide | N-[2-(2-methoxyphenyl)ethyl]-2-[(6-pyridin-3-yl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)sulfanyl]ethanamide | N-[2-(2-methoxyphenyl)ethyl]-2-[[6-(3-pyridinyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]thio]acetamide | N-[2-(2-methoxyphenyl)ethyl]-2-[[6-(3-pyridyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]thio]acetamide | SMR000324246 | cid_16194780
Type:
Small organic molecule
Emp. Form.:
C21H20N6O2S
Mol. Mass.:
420.487
SMILES:
COc1ccccc1CCNC(=O)CSc1nnc2ccc(nn12)-c1cccnc1
Structure:
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