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Target
Regulator of G-protein signaling 7
Ligand
BDBM47748
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 7
Synonyms:
RGS7 | RGS7_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57675.72
Organism:
Homo sapiens (Human)
Description:
P49802
Residue:
495
Sequence:
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
  
Inhibitor
Name:
BDBM47748
Synonyms:
5-acetyl-2-[[5-(4-ketocyclohexa-2,5-dien-1-ylidene)-3-isoxazoline-3-carbonyl]amino]-4-methyl-thiophene-3-carboxylic acid ethyl ester | 5-acetyl-4-methyl-2-[[oxo-[5-(4-oxo-1-cyclohexa-2,5-dienylidene)-2H-isoxazol-3-yl]methyl]amino]-3-thiophenecarboxylic acid ethyl ester | MLS000586972 | SMR000208902 | cid_15944756 | ethyl 5-acetyl-2-({[5-(4-hydroxyphenyl)isoxazol-3-yl]carbonyl}amino)-4-methylthiophene-3-carboxylate | ethyl 5-acetyl-4-methyl-2-[[5-(4-oxocyclohexa-2,5-dien-1-ylidene)-2H-1,2-oxazole-3-carbonyl]amino]thiophene-3-carboxylate | ethyl 5-ethanoyl-4-methyl-2-[[5-(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)-2H-1,2-oxazol-3-yl]carbonylamino]thiophene-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C20H18N2O6S
Mol. Mass.:
414.432
SMILES:
CCOC(=O)c1c(C)c(sc1NC(=O)c1cc(on1)-c1ccc(O)cc1)C(C)=O
Structure:
Search PDB for entries with ligand similarity: