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Target
Regulator of G-protein signaling 7
Ligand
BDBM47749
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 7
Synonyms:
RGS7 | RGS7_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57675.72
Organism:
Homo sapiens (Human)
Description:
P49802
Residue:
495
Sequence:
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
  
Inhibitor
Name:
BDBM47749
Synonyms:
3-[5-(1,3-benzodioxol-5-ylmethylamino)-1,3,4-thiadiazol-2-yl]-8-ethoxy-1-benzopyran-2-one | 3-[5-(1,3-benzodioxol-5-ylmethylamino)-1,3,4-thiadiazol-2-yl]-8-ethoxy-chromen-2-one | 3-[5-(1,3-benzodioxol-5-ylmethylamino)-1,3,4-thiadiazol-2-yl]-8-ethoxychromen-2-one | 3-{5-[(1,3-benzodioxol-5-ylmethyl)amino]-1,3,4-thiadiazol-2-yl}-8-ethoxy-2H-chromen-2-one | 8-ethoxy-3-[5-(piperonylamino)-1,3,4-thiadiazol-2-yl]coumarin | MLS000583496 | SMR000206682 | cid_5103647
Type:
Small organic molecule
Emp. Form.:
C21H17N3O5S
Mol. Mass.:
423.442
SMILES:
CCOc1cccc2cc(-c3nnc(NCc4ccc5OCOc5c4)s3)c(=O)oc12
Structure:
Search PDB for entries with ligand similarity: