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Target
Regulator of G-protein signaling 7
Ligand
BDBM47774
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 7
Synonyms:
RGS7 | RGS7_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57675.72
Organism:
Homo sapiens (Human)
Description:
P49802
Residue:
495
Sequence:
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
  
Inhibitor
Name:
BDBM47774
Synonyms:
MLS000621789 | N-(3-chloranyl-4-methyl-phenyl)-2-[4-oxidanylidene-3-(3-piperidin-1-ylpropyl)quinazolin-2-yl]sulfanyl-ethanamide | N-(3-chloro-4-methyl-phenyl)-2-[[4-keto-3-(3-piperidinopropyl)quinazolin-2-yl]thio]acetamide | N-(3-chloro-4-methylphenyl)-2-[4-oxo-3-(3-piperidin-1-ylpropyl)quinazolin-2-yl]sulfanylacetamide | N-(3-chloro-4-methylphenyl)-2-[[4-oxo-3-[3-(1-piperidinyl)propyl]-2-quinazolinyl]thio]acetamide | N-(3-chloro-4-methylphenyl)-2-{[4-oxo-3-(3-piperidin-1-ylpropyl)-3,4-dihydroquinazolin-2-yl]thio}acetamide | SMR000310716 | cid_4132205
Type:
Small organic molecule
Emp. Form.:
C25H29ClN4O2S
Mol. Mass.:
485.041
SMILES:
Cc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCN2CCCCC2)cc1Cl
Structure:
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