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Target
Regulator of G-protein signaling 7
Ligand
BDBM47781
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 7
Synonyms:
RGS7 | RGS7_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57675.72
Organism:
Homo sapiens (Human)
Description:
P49802
Residue:
495
Sequence:
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
  
Inhibitor
Name:
BDBM47781
Synonyms:
5-[4-[hydroxy(diphenyl)methyl]-1-piperidinyl]-5-oxopentanoic acid | 5-[4-[hydroxy(diphenyl)methyl]piperidin-1-yl]-5-oxopentanoic acid | 5-[4-[hydroxy(diphenyl)methyl]piperidino]-5-keto-valeric acid | 5-[4-[oxidanyl(diphenyl)methyl]piperidin-1-yl]-5-oxidanylidene-pentanoic acid | MLS000715040 | SMR000275019 | cid_1074070
Type:
Small organic molecule
Emp. Form.:
C23H27NO4
Mol. Mass.:
381.4648
SMILES:
OC(=O)CCCC(=O)N1CCC(CC1)C(O)(c1ccccc1)c1ccccc1
Structure:
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