Reaction Details Report a problem with these data
Target
Regulator of G-protein signaling 19
Ligand
BDBM47718
Substrate
n/a
Meas. Tech.
Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS19-Galphao.
EC50
>30000±n/a nM
Citation
 PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS19-Galphao. PubChem Bioassay (2009)[AID] 
Target
Name:
Regulator of G-protein signaling 19
Synonyms:
G protein signalling regulator 19 | GAIP | GNAI3IP | RGS19 | RGS19_HUMAN | Regulator of G-protein signaling 19 (RGS19)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
24631.38
Organism:
Homo sapiens (Human)
Description:
gi_86990435
Residue:
217
Sequence:
MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFWLACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDAQLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA
  
Inhibitor
Name:
BDBM47718
Synonyms:
2-[4-(3-Cyclohexyl-ureido)-phenyl]-3,3,3-trifluoro-2-hydroxy-propionic acid methyl ester | 2-[4-(cyclohexylcarbamoylamino)phenyl]-3,3,3-trifluoro-2-hydroxy-propionic acid methyl ester | 2-[4-[[(cyclohexylamino)-oxomethyl]amino]phenyl]-3,3,3-trifluoro-2-hydroxypropanoic acid methyl ester | MLS000554163 | SMR000146480 | cid_3767936 | methyl 2-[4-(cyclohexylcarbamoylamino)phenyl]-3,3,3-trifluoro-2-hydroxypropanoate | methyl 2-[4-(cyclohexylcarbamoylamino)phenyl]-3,3,3-tris(fluoranyl)-2-oxidanyl-propanoate
Type:
Small organic molecule
Emp. Form.:
C17H21F3N2O4
Mol. Mass.:
374.3548
SMILES:
COC(=O)C(O)(c1ccc(NC(=O)NC2CCCCC2)cc1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: