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Target
3C-like protease
Ligand
BDBM47928
Substrate
n/a
Meas. Tech.
QFRET-based dose response biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro)
IC50
34276±n/a nM
Citation
 PubChem, PC QFRET-based dose response biochemical high throughput screening assay to identify inhibitors of the SARS coronavirus 3C-like Protease (3CLPro) PubChem Bioassay (2009)[AID] 
Target
Name:
3C-like protease
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
33462.05
Organism:
Avian infectious bronchitis virus
Description:
gi_73745819
Residue:
307
Sequence:
SGFKKLVSPSSAVEKCIVSVSYRGNNLNGLWLGDSIYCPRHVLGKFSGDQWGDVLNLANNHEFEVVTQNGVTLNVVSRRLKGAVLILQTAVANAETPKYKFVKANCGDSFTIACSYGGTVIGLYPVTMRSNGTIRASFLAGACGSVGFNIEKGVVNFFYMHHLELPNALHTGTDLMGEFYGGYVDEEVAQRVPPDNLVTNNIVAWLYAAIISVKESSFSQPKWLESTTVSIEDYNRWASDNGFTPFSTSTAITKLSAITGVDVCKLLRTIMVKSAQWGSDPILGQYNFEDELTPESVFNQVGGVRLQ
  
Inhibitor
Name:
BDBM47928
Synonyms:
(5E)-1-(2-fluorophenyl)-5-[[1-(2-keto-2-morpholino-ethyl)indol-3-yl]methylene]barbituric acid | (5E)-1-(2-fluorophenyl)-5-[[1-(2-morpholin-4-yl-2-oxidanylidene-ethyl)indol-3-yl]methylidene]-1,3-diazinane-2,4,6-trione | (5E)-1-(2-fluorophenyl)-5-[[1-(2-morpholin-4-yl-2-oxoethyl)indol-3-yl]methylidene]-1,3-diazinane-2,4,6-trione | (5E)-1-(2-fluorophenyl)-5-[[1-[2-(4-morpholinyl)-2-oxoethyl]-3-indolyl]methylidene]-1,3-diazinane-2,4,6-trione | MLS000950093 | SMR000619974 | cid_5897880
Type:
Small organic molecule
Emp. Form.:
C25H21FN4O5
Mol. Mass.:
476.4564
SMILES:
Fc1ccccc1N1C(=O)NC(=O)C(=Cc2cn(CC(=O)N3CCOCC3)c3ccccc23)C1=O |w:14.15|
Structure:
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