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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM48048
Substrate
n/a
Meas. Tech.
Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency
EC50
0.0102±n/a nM
Citation
 PubChem, PC Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator(PAM): Analog Potency PubChem Bioassay (2010)[AID] 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_RAT | Cholinergic, muscarinic M4 | Chrm-4 | Chrm4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52841.70
Organism:
RAT
Description:
Cholinergic, muscarinic M4 CHRM4 RAT::P08485
Residue:
477
Sequence:
MNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM48048
Synonyms:
3-amino-4,6-dimethyl-N-(3-methylbenzyl)thieno[2,3-b]pyridine-2-carboxamide | 3-amino-4,6-dimethyl-N-[(3-methylphenyl)methyl]-2-thieno[2,3-b]pyridinecarboxamide | 3-amino-4,6-dimethyl-N-[(3-methylphenyl)methyl]thieno[2,3-b]pyridine-2-carboxamide | 3-azanyl-4,6-dimethyl-N-[(3-methylphenyl)methyl]thieno[2,3-b]pyridine-2-carboxamide | VU0402474-1 | cid_44176128
Type:
Small organic molecule
Emp. Form.:
C18H19N3OS
Mol. Mass.:
325.428
SMILES:
Cc1cccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)c1
Structure:
Search PDB for entries with ligand similarity: